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1

Chronic interstitial lung diseases in children: diagnosis approaches

Nathan, Nadia, Berdah, Laura, Borensztajn, Keren, Clement, Annick

Journal:

Expert Review of Respiratory Medicine

Year:

2018

Language:

english

File:

PDF, 932 KB

english, 2018

2

Characterization of two novel splice site mutations in human factor VII gene causing severe plasma factor VII deficiency and bleeding diathesis

Keren Borensztajn, Ouerdia Chafa, Martine Alhenc-Gelas, Siham Salha, Abderrezak Reghis, Anne-Marie Fischer, Jacqueline Tapon-Bretaudière

Journal:

British Journal of Haematology

Year:

2002

Language:

english

File:

PDF, 109 KB

english, 2002

3

A mechanism for thrombin-dependent lung metastasis in patients with osteosarcoma

Keren Borensztajn, Hella Aberson, Angelique P. Groot, Maikel P. Peppelenbosch, C. Arnold Spek

Journal:

British Journal of Haematology

Year:

2009

Language:

english

File:

PDF, 119 KB

english, 2009

4

FXa-induced intracellular signaling links coagulation to neoangiogenesis: Potential implications for fibrosis

Keren Borensztajn, Hella Aberson, Maikel P. Peppelenbosch, C. Arnold Spek

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Year:

2009

Language:

english

File:

PDF, 365 KB

english, 2009

5

Sonic hedgehog induces transcription-independent cytoskeletal rearrangement and migration regulated by arachidonate metabolites

Maarten F. Bijlsma, Keren S. Borensztajn, Henk Roelink, Maikel P. Peppelenbosch, C. Arnold Spek

Journal:

Cellular Signalling

Year:

2007

Language:

english

File:

PDF, 815 KB

english, 2007

6

Coagulation factor Xa drives tumor cells into apoptosis through BH3-only protein Bim up-regulation

Keren S. Borensztajn, Maarten F. Bijlsma, Angelique P. Groot, Lois W. Brüggemann, Henri H. Versteeg, Pieter H. Reitsma, Maikel P. Peppelenbosch, C. Arnold Spek

Journal:

Experimental Cell Research

Year:

2007

Language:

english

File:

PDF, 1.24 MB

english, 2007

7

The coagulation factor Xa/protease activated receptor-2 axis in the progression of liver fibrosis: a multifaceted paradigm

Keren Borensztajn, Jan H. Von Der Thüsen, Maikel P. Peppelenbosch, C. Arnold Spek

Journal:

Journal of Cellular and Molecular Medicine

Year:

2010

Language:

english

File:

PDF, 719 KB

english, 2010

8

IGF-1 Has Plaque-Stabilizing Effects in Atherosclerosis by Altering Vascular Smooth Muscle Cell Phenotype

Jan H. von der Thüsen, Keren S. Borensztajn, Silvia Moimas, Sandra van Heiningen, Peter Teeling, Theo J.C. van Berkel, Erik A.L. Biessen

Journal:

The American Journal of Pathology

Year:

2011

Language:

english

File:

PDF, 2.18 MB

english, 2011

9

Factor Xa: at the crossroads between coagulation and signaling in physiology and disease

Keren Borensztajn, Maikel P. Peppelenbosch, C. Arnold Spek

Journal:

Trends in Molecular Medicine

Year:

2008

Language:

english

File:

PDF, 1.18 MB

english, 2008

10

Inherited factor VII deficiency: identification of two novel mutations (A191V and T239P) in the catalytic domain

Keren Borensztajn, Ouerdia Chafa, Bernard Le Bonniec, Henri Wajcman, Abderrezak Reghis, Anne-Marie Fischer, Jacqueline Tapon-Bretaudière

Journal:

Thrombosis Research

Year:

2005

Language:

english

File:

PDF, 113 KB

english, 2005

11

Characterization of the intracellular signalling capacity of natural FXa mutants with reduced pro-coagulant activity

Monia Monti, Keren S. Borensztajn, Mirko Pinotti, Alessandro Canella, Alessio Branchini, Giovanna Marchetti, Pieter H. Reitsma, Francesco Bernardi, C. Arnold Spek

Journal:

Thrombosis Research

Year:

2009

Language:

english

File:

PDF, 484 KB

english, 2009

12

Coagulation Factor Xa inhibits cancer cell migration via Protease-activated receptor-1 activation

Keren Borensztajn, Maarten F. Bijlsma, Pieter H. Reitsma, Maikel P. Peppelenbosch, C. Arnold Spek

Journal:

Thrombosis Research

Year:

2009

Language:

english

File:

PDF, 425 KB

english, 2009

13

Coagulation Factor Xa inhibits cancer cell migration via LIMK1-mediated cofilin inactivation

Keren Borensztajn, Maikel P. Peppelenbosch, C. Arnold Spek

Journal:

Thrombosis Research

Year:

2010

Language:

english

File:

PDF, 339 KB

english, 2010

14

Coagulation factor Xa signaling: the link between coagulation and inflammatory bowel disease?

Keren Borensztajn, Maikel P. Peppelenbosch, C. Arnold Spek

Journal:

Trends in Pharmacological Sciences

Year:

2009

Language:

english

File:

PDF, 862 KB

english, 2009

15

Factor Xa Stimulates Proinflammatory and Profibrotic Responses in Fibroblasts via Protease-Activated Receptor-2 Activation

Keren Borensztajn, Jurriën Stiekema, Sebastiaan Nijmeijer, Pieter H. Reitsma, Maikel P. Peppelenbosch, C. Arnold Spek

Journal:

The American Journal of Pathology

Year:

2008

Language:

english

File:

PDF, 965 KB

english, 2008

16

Protease-Activated Receptor-2 Induces Myofibroblast Differentiation and Tissue Factor Up-Regulation during Bleomycin-Induced Lung Injury: Potential Role in Pulmonary Fibrosis

Keren Borensztajn, Paul Bresser, Chris van der Loos, Ilze Bot, Bernt van den Blink, Michael A. den Bakker, Joost Daalhuisen, Angelique P. Groot, Maikel P. Peppelenbosch, Jan H. von der Thüsen, C. Arno

Journal:

The American Journal of Pathology

Year:

2010

Language:

english

File:

PDF, 1.80 MB

english, 2010

17

Functional consequences of prolactin signalling in endothelial cells: a potential link with angiogenesis in pathophysiology?

Anne Q. Reuwer, Patrycja Nowak-Sliwinska, Laurie A. Mans, Chris M. van der Loos, Jan H. von der Thüsen, Marcel Th. B. Twickler, C. Arnold Spek, Vincent Goffin, Arjan W. Griffioen, Keren S. Borensztajn

Journal:

Journal of Cellular and Molecular Medicine

Year:

2012

Language:

english

File:

PDF, 1.19 MB

english, 2012

18

Fibroblasts: the missing link between fibrotic lung diseases of different etiologies?

Bruno Crestani, Valerie Besnard, Laurent Plantier, Keren Borensztajn, Arnaud Mailleux

Journal:

Respiratory Research

Year:

2013

Language:

english

File:

PDF, 111 KB

english, 2013

19

Combination therapy: the future of management for idiopathic pulmonary fibrosis?

Wuyts, Wim A, Antoniou, Katerina M, Borensztajn, Keren, Costabel, Ulrich, Cottin, Vincent, Crestani, Bruno, Grutters, Jan C, Maher, Toby M, Poletti, Venerino, Richeldi, Luca, Vancheri, Carlo, Wells, A

Journal:

The Lancet Respiratory Medicine

Year:

2014

Language:

english

File:

PDF, 114 KB

english, 2014

20

Blood coagulation factor Xa as an emerging drug target

Borensztajn, Keren, Spek, C Arnold

Journal:

Expert Opinion on Therapeutic Targets

Year:

2011

Language:

english

File:

PDF, 306 KB

english, 2011

21

Protease-activated receptor (PAR)-2 is required for PAR-1 signalling in pulmonary fibrosis

Lin, Cong, von der Thüsen, Jan, Daalhuisen, Joost, ten Brink, Marieke, Crestani, Bruno, van der Poll, Tom, Borensztajn, Keren, Spek, C. Arnold

Journal:

Journal of Cellular and Molecular Medicine

Year:

2015

Language:

english

File:

PDF, 1.93 MB

english, 2015

22

Idiopathic Pulmonary Fibrosis: From Epithelial Injury to Biomarkers - Insights from the Bench Side

Borensztajn, Keren, Crestani, Bruno, Kolb, Martin

Journal:

Year:

2013

Language:

english

File:

PDF, 248 KB

english, 2013

23

Oriented Scanning Is the Leading Mechanism Underlying 5′ Splice Site Selection in Mammals

Borensztajn, Keren, Sobrier, Marie-Laure, Duquesnoy, Philippe, Fischer, Anne-Marie, Tapon-Bretaudière, Jacqueline, Amselem, Serge

Journal:

Year:

2006

Language:

english

File:

PDF, 609 KB

english, 2006

24

CCAAT-enhancer binding protein delta (C/EBPδ) attenuates tubular injury and tubulointerstitial fibrogenesis during chronic obstructive nephropathy

Duitman, JanWillem, Borensztajn, Keren S, Pulskens, Willem PC, Leemans, Jaklien C, Florquin, Sandrine, Spek, C Arnold

Journal:

Laboratory Investigation

Year:

2014

Language:

english

File:

PDF, 779 KB

english, 2014

25

Hepatocyte Growth Factor and Lung Fibrosis

Crestani, Bruno, Marchand-Adam, Sylvain, Quesnel, Christophe, Plantier, Laurent, Borensztajn, Keren, Marchal, Joelle, Mailleux, Arnaud, Soler, Paul, Dehoux, Monique

Journal:

Proceedings of the American Thoracic Society

Year:

2012

Language:

english

File:

PDF, 268 KB

english, 2012

26

Increased Mortality during Bleomycin-induced Pulmonary Fibrosis due to Low Endogenous Activated Protein C Levels

Lin, Cong, von der Thüsen, Jan, van der Poll, Tom, Borensztajn, Keren, Spek, C. Arnold

Journal:

American Journal of Respiratory and Critical Care Medicine

Year:

2015

Language:

english

File:

PDF, 983 KB

english, 2015

27

Protease-Activated Receptors, Apoptosis and Tumor Growth

Borensztajn, Keren S., Spek, C. Arnold

Journal:

Pathophysiology of Haemostasis and Thrombosis

Year:

2007

Language:

english

File:

PDF, 827 KB

english, 2007

28

Airway smooth muscle enlargement is associated with protease-activated receptor 2/ligand overexpression in patients with difficult-to-control severe asthma

Aubier, Michel, Thabut, Gabriel, Hamidi, Fatima, Guillou, Noëlline, Brard, Julien, Dombret, Marie-Christine, Borensztajn, Keren, Aitilalne, Brahim, Poirier, Isabelle, Roland-Nicaise, Pascale, Taillé,

Journal:

Journal of Allergy and Clinical Immunology

Year:

2016

Language:

english

File:

PDF, 2.68 MB

english, 2016

29

Neuropeptide Receptors in Intestinal Disease: Physiology and Therapeutic Potential

Snoek, Susanne, Borensztajn, Keren, van den Wijngaard, Rene, de Jonge, Wouter

Journal:

Current Pharmaceutical Design

Year:

2010

Language:

english

File:

PDF, 461 KB

english, 2010

30

The Role of Coagulation in Chronic Inflammatory Disorders: A Jack of All Trades

S. Borensztajn, Keren, H. von der Thusen, Jan, Arnold Spek, C.

Journal:

Current Pharmaceutical Design

Year:

2011

Language:

english

File:

PDF, 128 KB

english, 2011

31

Protease-Activated Receptor 2 Blocking Peptide Counteracts Endotoxin-Induced Inflammation and Coagulation and Ameliorates Renal Fibrin Deposition in a Rat Model of Acute Renal Failure

Spek, C. Arnold, Brüggemann, Lois W., Borensztajn, Keren S.

Journal:

Year:

2010

Language:

english

File:

PDF, 100 KB

english, 2010

32

High endogenous activated protein C levels attenuates bleomycin-induced pulmonary fibrosis

Lin, Cong, von der Thüsen, Jan, Isermann, Berend, Weiler, Hartmut, van der Poll, Tom, Borensztajn, Keren, Spek, Chris A.

Journal:

Journal of Cellular and Molecular Medicine

Year:

2016

Language:

english

File:

PDF, 608 KB

english, 2016

33

Potential importance of protease activated receptor (PAR)-1 expression in the tumor stroma of non-small-cell lung cancer

Lin, Cong, Majoor, Christof J., Roelofs, Joris J. T. H., de Kruif, Martijn D., Horlings, Hugo M., Borensztajn, Keren, Spek, C. Arnold

Journal:

Year:

2017

Language:

english

File:

PDF, 3.78 MB

english, 2017

34

Protease-Activated Receptor 2 Facilitates Bacterial Dissemination in Pneumococcal Pneumonia

van den Boogaard, Florry E, Brands, Xanthe, Duitman, JanWillem, de Stoppelaar, Sacha F, Borensztajn, Keren S, Roelofs, Joris J T H, Hollenberg, Morley D, Spek, C Arnold, Schultz, Marcus J, van ‘t Veer

Journal:

The Journal of Infectious Diseases

Year:

2018

Language:

english

File:

PDF, 445 KB

english, 2018

35

Genetic causes and clinical management of pediatric interstitial lung diseases

Nathan, Nadia, Borensztajn, Keren, Clement, Annick

Journal:

Current Opinion in Pulmonary Medicine

Year:

2018

Language:

english

File:

PDF, 255 KB

english, 2018

36

Anticoagulant therapy of cancer patients: Will patient selection increase overall survival?

Spek, C. Arnold, Versteeg, Henri, Borensztajn, Keren

Journal:

Thrombosis and Haemostasis

Year:

2015

Language:

english

File:

PDF, 426 KB

english, 2015

37

Protease Activated Receptor-1 Deficiency Diminishes Bleomycin-Induced Skin Fibrosis

Duitman, Jan Willem, Ruela-de-Sousa, Roberta R., Shi, Kun, de Boer, Onno J., Borensztajn, Keren S., Florquin, Sandrine, Peppelenbosch, Maikel P., Spek, C. Arnold

Journal:

Molecular Medicine

Year:

2014

Language:

english

File:

PDF, 5.94 MB

english, 2014

38

Pharmacological Targeting of Protease-Activated Receptor 2 Affords Protection from Bleomycin-Induced Pulmonary Fibrosis

Lin, Cong, von der Thüsen, Jan, Daalhuisen, Joost, ten Brink, Marieke, Crestani, Bruno, van der Poll, Tom, Borensztajn, Keren, Spek, C. Arnold

Journal:

Molecular Medicine

Year:

2015

Language:

english

File:

PDF, 5.77 MB

english, 2015